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Hena kulanga-langa minsyu kuuba-uba kulakonzya kujana bulwazi bwa Alzheimer bwakusaanguna, akujalula nzila yakuchita mapulogilamu aakulanga-langa bantu banji? Chiiyo chipya cha Frontiers in Aging Neuroscience chitondezya eezi. Basikuvwuntauzya bakasunka nkamu mpati yabantu bachiswa bulwazi bwa Alzheimer's ibajisi bulwazi bwiindene-indene alimwi abantu batakwe buumi bubotu ibakali boongo kabotu kutegwa bazyibe kwiimpana kwazitondezyo zyaminsyu.
Bakajana kuti asidi yafoomu mumulota nchitondezyo chakucheya kwakuyeeya kwamuntu mpawo chilakonzya kutondezya kutalika kwabulwazi bwa Alzheimer. Nzila ziliwo zyakujana bulwazi bwa Alzheimer ziladula, tazigwasyi pe, alimwi tazikonzyi kubelesegwa mukulanga-langa lyoonse. Eezi zyaamba kuti balwazi biingi balajanwa buyo kuti kwachiindi chilamfu kuti bachitwe kabotu. Nokuba boobo, nzila iitabelesyi misamu iikola, iitaduli, alimwi iitakatazyi kubelesya nzila yakupima minsyu ya formic acid ilakonzya kuba njiyonya bamadokotela njobakumbila kuti bavwuntauzye kakuchili chiindi.
"Bulwazi bwa Alzheimer mbulwazi butamani alimwi butasilikiki, chaamba kuti bulakonzya kuyaambele akuzumanana kwamyaka myiingi kakutanaba kulezya kwakuyeeya," balembi mbobaamba. "Zibeela zyakusaanguna zyabulwazi zilachitika kakutanaba chiindi chakubula maanu, eecho chili mbuli windo lyangolida lyakugwasya akusilikwa. Aboobo, kulanga-langa kupati kwakusaanguna kwabulwazi bwa Alzheimer's kubantu bachembeede kulayandika."
Aboobo, ikuti naa kufwambaana kunjilila kulayandika, nkaambo nzi ncotutabi amapulogilamu aakulanga-langa bulwazi bwa Alzheimer bwakusaanguna? Penzi lili munzila zyakupima zilwazi nzyobabelesya bamadokotela lino. Eezi zibikkilizya positron emission tomography yabongo, eeyo iidula alimwi iipa kuti balwazi kabajisi radiation. Alimwi kuli nzila zyakusunka zitondezyo zyabuumi zikonzya kujana bulwazi bwa Alzheimer, pesi ziyandika kugwisigwa bulowa naa kugonkwa mumubili kutegwa kujanike maanzi aamubongo, alo balwazi ngobakonzya kuleka.
Nokuba boobo, kulanga-langa minsyu takunjili mumubili alimwi nkuubauba, aboobo nkubotu kapati mukulanga-langa bantu banji. Nikuba kuti basikuvwuntauzya bakajana zitondezyo zya Alzheimer's mumulota, taakwe pe zikonzya kugwasya kujana bulwazi oobu kumatalikilo, eezi zyaamba kuti nzila mbotu yakusilikwa kakuchili chiindi taikonzyi kuzyibwa pe.
Basikuvwuntauzya bakachita lwiiyo lupya bakavwuntauzya kale musamu uutegwa formaldehyde mbuli chitondezyo cha Alzheimer. Nokuba boobo, kuli busena bwakusumpula mukuziba malwazi kakuchili chiindi. Mukuvwuntauzya kwachiindi chifwiifwi, bakabikkila maanu ku formate, musamu wa formaldehyde, kuti babone naa ulakonzya kubeleka kabotu mbuli chitondezyo.
Mweelwe wabantu bali 574 bakatola lubazu mukwiiya ooku, mpawo aabo bakatola lubazu bakali basikulisungula batakwe maanu naakuti bakali abukkale bwiindene-indene bwakuyaambele kwamalwazi, kuzwa kukumana kwamizeezo kusikila kukuchiswa koonse. Basikuvwuntauzya bakavwuntauzya minsyu agazi kuzwa kuli baabo bakatola lubazu mpawo bakachita buvwuntauzi bwaboongo.
Buvwuntauzi bwakajana kuti zyeelelo zya asidi mumulota zyakalisumpukide kapati mutubunga toonse twabulwazi bwa Alzheimer alimwi zyakali kweendelana akuceya kwakuyeeya kweelanisigwa abaabo bakali kupona kabotu, kubikkilizya akabunga kakusaanguna kakuceya kwakuyeeya. Eezi zitondezya kuti asidi yafoomu ilakonzya kubeleka mbuli chitondezyo chabulwazi bwa Alzheimer.
Chakugambya, aawo basikuvwuntauzya nibakalanga-langa mweelwe wa formate mumulota antoomwe a Alzheimer's blood biomarkers, bakajana kuti balakonzya kuzyiba kabotu-kabotu chiindi chabulwazi mulwazi nchali mumo. Nokuba boobo, buvwuntauzi bumbi buyandika kutegwa kumvwisisisye kujatana aakati kabulwazi bwa Alzheimer a formic acid.
"Asidi ya formic acid yamumulota yakatondeezya kuti ilakonzya kugwasya kapati mukulanga-langa bulwazi bwa Alzheimer," balembi bakaamba. "Kusunkwa kwaminsyu yabulwazi bwa Alzheimer nchintu chibotu alimwi tachiyandiki mali manji alimwi kweelede kubikkilizyigwa mukulanga-langa buumi bwabantu bachembeede."
Wang, Y. abamwi. (2022) Kulanga-langa kwakacitwa kabotu-kabotu kwa asidi ya formic mumulota mbuli chitondezyo chipya chabulwazi bwa Alzheimer. Migaano mubuumi bwabongo bwakucembaala. doi.org/10.3389/fnagi.2022.1046066.
Ma tags: kuchembaala, bulwazi bwa Alzheimer, zitondezyo zyabuumi, bulowa, boongo, bulwazi butasilikiki, butasilikiki, misamu iikola, bulwazi bwakubula maanu, nzila zyakujana malwazi, bamadokotela, formaldehyde, lwiiyo lwabongo, positron emission tomography, buvwuntauzi, tomography, urinalysis
Ku Pittcon 2023 mu Philadelphia, Pennsylvania, twakabuzya-buzya Mufundisi Joseph Wang, sikuzunda wa Ralph N. Adams Prize mu Analytical Chemistry, aatala akubeleka kwa biosensor technology.
Mukubuzya-buzya ooku, twabandika aatala akugwisigwa kwabulowa bwakuyoya akuti inga kwaba chibelesyo chigwasya biyeni mukwiiya zitondezyo zyabuumi bwakusaanguna kuzyiba malwazi a Mariana Leal, Mupati wa Kabunga ku Owlstone Medical.
Mbuli chibeela chakulangisisya kwesu kwa SLAS US 2023, twabandika aatala a laboratory yakumbele akuti inga yaboneka biyeni a Luigi Da Via, Mupati wa Kabunga Kasumpula Musunko wa GSK.
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